BH4 Assist is an additional supplement choice for TRIAD 2 BRAIN/DEPRESSION support. BH4-Assist helps to maintain proper levels of tetrahydrobiopterin (BH4). BH4 plays a critical role in both neurotransmitter and nitric oxide production. It can be depleted by genetic polymorphisms in MTHFR A1298C, DHFR, high levels of ammonia (from CBS mutations), oxidative stress, or lack of SAMe or NADH. This formulation contains Royal Jelly, which has naturally occurring BH4, folinic acid (as calcium folate and 5-MTHF 2:1), 6S-5-MTHF, SAMe and lithium to support production of BH4.